Maximizing the Therapeutic Potential of HSP90 Inhibitors
نویسندگان
چکیده
منابع مشابه
Maximizing the Therapeutic Potential of HSP90 Inhibitors.
HSP90 is required for maintaining the stability and activity of a diverse group of client proteins, including protein kinases, transcription factors, and steroid hormone receptors involved in cell signaling, proliferation, survival, oncogenesis, and cancer progression. Inhibition of HSP90 alters the HSP90-client protein complex, leading to reduced activity, misfolding, ubiquitination, and, ulti...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2015
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-15-0234